<p>Play 49ers Pick 'Em presented by Vivid Seats and answer the most questions correctly for your chance to win a $100 Vivid Seats gift card and/or signed 49ers merchandise.<br /><br />Come back each week to the season-long leaderboard <a target="_blank" rel="noopener noreferrer nofollow" href="https://visit.wit.win/v1?u=https%3A%2F%2Fweb.witcontests.com%2F49ers%2Fcampaign%2F49ers-pickem-2026-27%2Fleaderboard">HERE</a> to see who’s in the running for the 2026 regular season grand prize!</p>

Over or under: 10.5 combined tackles by Fred Warner?

Which team will score more points in the first half?

Will the 49ers defense hold Seattle to over or under 210.5 passing yards?

Over or under: 25.5 rushing yards for Kaelon Black?

Will the 49ers convert a 4th down attempt?